High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Identifieur interne : 000615 ( Main/Exploration ); précédent : 000614; suivant : 000616High nigral iron deposition in LRRK2 and Parkin mutation carriers using R2* relaxometry.
Auteurs : Nadya Pyatigorskaya [France] ; Michael Sharman [France] ; Jean-Christophe Corvol [France] ; Romain Valabregue [France] ; Lydia Yahia-Cherif [France] ; Fabrice Poupon [France] ; Florence Cormier-Dequaire [France] ; Hartwig Siebner ; Stephan Klebe [France] ; Marie Vidailhet [France] ; Alexis Brice [France] ; Stephane Lehéricy [France]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2015.
English descriptors
- KwdEn :
- Adult, Aged, Female, Globus Pallidus (metabolism), Heterozygote, Humans, Iron (metabolism), Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Magnetic Resonance Imaging (methods), Male, Middle Aged, Mutation, Neostriatum (metabolism), Parkinson Disease (genetics), Parkinson Disease (metabolism), Protein-Serine-Threonine Kinases (genetics), Substantia Nigra (metabolism), Thalamus (metabolism), Ubiquitin-Protein Ligases (genetics).
- MESH :
- chemical , genetics : Protein-Serine-Threonine Kinases, Ubiquitin-Protein Ligases.
- chemical , metabolism : Iron.
- genetics : Parkinson Disease.
- metabolism : Globus Pallidus, Neostriatum, Parkinson Disease, Substantia Nigra, Thalamus.
- methods : Magnetic Resonance Imaging.
- Adult, Aged, Female, Heterozygote, Humans, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Male, Middle Aged, Mutation.
Abstract
The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate.
DOI: 10.1002/mds.26218
PubMed: 26011561
Affiliations:
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Le document en format XML
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type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Poupon, Fabrice" sort="Poupon, Fabrice" uniqKey="Poupon F" first="Fabrice" last="Poupon">Fabrice Poupon</name><affiliation wicri:level="3"><nlm:affiliation>NeuroSpin, Commissariat à l'Energie Atomique (CEA), Gif-Sur-Yvette, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>NeuroSpin, Commissariat à l'Energie Atomique (CEA), Gif-Sur-Yvette</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Gif-sur-Yvette</settlement></placeName></affiliation></author><author><name sortKey="Cormier Dequaire, Florence" sort="Cormier Dequaire, Florence" uniqKey="Cormier Dequaire F" first="Florence" last="Cormier-Dequaire">Florence Cormier-Dequaire</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name><affiliation><nlm:affiliation>Hvidovre Hospital, University of Copenhagen, Centre for Functional and Diagnostic Imaging and Research, Danish Research Centre for Magnetic Resonance (DRCMR).</nlm:affiliation><wicri:noCountry code="subField">Danish Research Centre for Magnetic Resonance (DRCMR)</wicri:noCountry></affiliation></author><author><name sortKey="Klebe, Stephan" sort="Klebe, Stephan" uniqKey="Klebe S" first="Stephan" last="Klebe">Stephan Klebe</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><affiliation wicri:level="4"><nlm:affiliation>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>ICM, Université Pierre et Marie Curie (UPMC Univ Paris 6), Inserm UMR-S1127; CNRS, UMR 7225, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><affiliation wicri:level="3"><nlm:affiliation>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut du Cerveau et de la Moelle épinière-ICM, Centre de NeuroImagerie de Recherche-CENIR, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Globus Pallidus (metabolism)</term><term>Heterozygote</term><term>Humans</term><term>Iron (metabolism)</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Middle Aged</term><term>Mutation</term><term>Neostriatum (metabolism)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Protein-Serine-Threonine Kinases (genetics)</term><term>Substantia Nigra (metabolism)</term><term>Thalamus (metabolism)</term><term>Ubiquitin-Protein Ligases (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Protein-Serine-Threonine Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Iron</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Globus Pallidus</term><term>Neostriatum</term><term>Parkinson Disease</term><term>Substantia Nigra</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Heterozygote</term><term>Humans</term><term>Leucine-Rich Repeat Serine-Threonine Protein Kinase-2</term><term>Male</term><term>Middle Aged</term><term>Mutation</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The goal of this work was to investigate iron deposition in the basal ganglia and thalamus in symptomatic and asymptomatic leucine-rich repeat kinase 2 (LRRK2) and Parkin-associated Parkinson's disease (PD), using R2* relaxometry rate.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Gif-sur-Yvette</li><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><noCountry><name sortKey="Siebner, Hartwig" sort="Siebner, Hartwig" uniqKey="Siebner H" first="Hartwig" last="Siebner">Hartwig Siebner</name></noCountry><country name="France"><region name="Île-de-France"><name sortKey="Pyatigorskaya, Nadya" sort="Pyatigorskaya, Nadya" uniqKey="Pyatigorskaya N" first="Nadya" last="Pyatigorskaya">Nadya Pyatigorskaya</name></region><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><name sortKey="Cormier Dequaire, Florence" sort="Cormier Dequaire, Florence" uniqKey="Cormier Dequaire F" first="Florence" last="Cormier-Dequaire">Florence Cormier-Dequaire</name><name sortKey="Corvol, Jean Christophe" sort="Corvol, Jean Christophe" uniqKey="Corvol J" first="Jean-Christophe" last="Corvol">Jean-Christophe Corvol</name><name sortKey="Klebe, Stephan" sort="Klebe, Stephan" uniqKey="Klebe S" first="Stephan" last="Klebe">Stephan Klebe</name><name sortKey="Lehericy, Stephane" sort="Lehericy, Stephane" uniqKey="Lehericy S" first="Stephane" last="Lehéricy">Stephane Lehéricy</name><name sortKey="Poupon, Fabrice" sort="Poupon, Fabrice" uniqKey="Poupon F" first="Fabrice" last="Poupon">Fabrice Poupon</name><name sortKey="Sharman, Michael" sort="Sharman, Michael" uniqKey="Sharman M" first="Michael" last="Sharman">Michael Sharman</name><name sortKey="Valabregue, Romain" sort="Valabregue, Romain" uniqKey="Valabregue R" first="Romain" last="Valabregue">Romain Valabregue</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Yahia Cherif, Lydia" sort="Yahia Cherif, Lydia" uniqKey="Yahia Cherif L" first="Lydia" last="Yahia-Cherif">Lydia Yahia-Cherif</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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